Lethal concentration (LC 50) that causes death (resultingįrom a single or limited exposure) in 50 percent of the treatedĪnimals. Measure of acute toxicity is the lethal dose (LD 50) or The acute oral LD 50 in chickens ranges from 32 mg/kg to 102 mg/kg. Chlorpyrifos is highly toxic to chickens.The acute oral LD 50 in guinea pigs ranges from 500 to 504 mg/ Chlorpyrifos is moderately toxic to guinea pigs and sheep.The acute oral LD 50 in rabbits ranges from 1000 to 2000 mg/kg. Chlorpyrifos is slightly toxic to rabbits.1,2,11 See the text boxes on Toxicity Classification and LD 50/LC 50. 1 The oral LD 50 for mice is 60 mg/kg for rats it ranges from 95 to 270 mg/ Chlorpyrifos is moderately toxic to mice and rats.Is not well understood, although they occur in many mammalian systems. Chlorpyrifos also interacts with other enzymes, such as carboxylesterases and A-esterases.This causes an unbreakableīond to form between the phosphorous atom on chlorpyrifos and the active site of the ChE or NTE enzyme. Group from the chlorpyrifos residue produces a negative charge at the active site of the enzyme. Chlorpyrifos can cause permanent inhibition of the ChE or NTE enzymes, a process known as aging.Inhibition of the NTE enzyme results in loss of myelin and degeneration of axon fibers of the 10 Chlorpyrifos can inhibit NTE by binding to theĪctive site of the enzyme. Vessel development and protein synthesis in the central nervous system. The results demonstrated that NTE plays an essential role in placental development, blood The physiological functions of the neuropathy target esterase (NTE) enzyme were studied in genetically altered mice,.Red blood cell ChE inhibition in experimental animals at doses lower than those required to cause ChE inhibition in the

Chlorpyrifos affects ChE levels differently in various systems throughout the body.System, and on the surface of red blood cells. System, the junction of post-ganglionic parasympathetic neurons in exocrine glands and smooth and cardiac muscles,Īt pre- and post-ganglionic neurons in the autonomic nervous system, at neuromuscular junctions of the somatic nervous Acetylcholine is found throughout the mammalian nervous system, including at cholinergic synapses in the central nervous.The mode of action of chlorpyrifos is similar for target and non-target organisms.Parathion, thus, chlorpyrifos would not be effective against organophosphate-resistant insect populations. Chlorpyrifos shares a common mechanism of toxicity with other organophosphate insecticides such as malathion and.The neuronal cells, which leads to neurotoxicity and eventually death. 6 The resulting accumulation of ACh in the synaptic cleft causes overstimulation of When insects are exposed, chlorpyrifos binds to the active site of the cholinesterase (ChE) enzyme, which preventsīreakdown of ACh in the synaptic cleft. 4 Chlorpyrifos affects the nervous system by inhibiting the breakdown of acetylcholine (ACh), a neurotransmitter. Chlorpyrifos is a broad-spectrum insecticide which kills insects upon contact by affecting the normal function of the nervous.select your state then click on the link for 'State Products.' To find a list of products containing chlorpyrifos which are registered in your state, visit the website.The NPIC fact sheets on Signal Words and Inert or 'Other' Ingredients. See the pesticide label on the product and refer to

Toxicity of the active ingredient and other ingredients in the product.

Signal words for products containing chlorpyrifos may range from Caution to Danger.

Chlorpyrifos is a non-systemic insecticide designed to be effective by direct contact, ingestion, and inhalation.

Always readĪnd follow the label when applying pesticide products. Uses for individual products containing chlorpyrifos vary widely. Registered for indoor residential use only in the form of containerized baits. Including processed wood products, fence posts and utility poles, and toĬontrol public health pests such as mosquitoes and fire ants.

Chlorpyrifos is used on agricultural food and feed crops, cattle ear tags, golfĬourse turf, industrial plants and vehicles, non-structural wood treatments.

Soil Sorption Coefficient (K oc) 5: 360 to 31,000 depending on soil type and environmental.

m 3/mol, depending on the technique used.

Henry's constant may be determined by estimation or experimentally derived.

Octanol-Water Partition Coefficient (K ow) 2: 4.70.

Vapor pressure 4: 1.87 x 10 -5 mmHg at 25 ☌.

Mercaptan (thiol) odor, similar to the smell of sulfur compounds found in rotten

Chlorpyrifos is a colorless to white crystalline solid.

Chlorpyrifos Physical / Chemical Properties:

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